BDBM373968 (S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-3-yl)(methyl)amino)-3-methyl-N-(thiazol-4-yl)benzenesulfonamide formate::US10246453, Example 235::US10815229, Example 235

SMILES: CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1

InChI Key: InChIKey=MCZUVSMKLIOVFW-KRWDZBQOSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 373968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373968 ((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...) Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373968 ((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...) Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373968 ((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...) Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373968 ((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...) Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373968 ((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...) Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020)
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM373968 ((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...) Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1 |r| Show InChI InChI=1S/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair