BDBM375553 4-(6-(4-(1′-methyl-4,4′-bipiperidine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile::US9908886, Example 105

SMILES: CN1CCC(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1

InChI Key: InChIKey=AVAIDIQUQPNMDV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375553   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM375553 (4-(6-(4-(1′-methyl-4,4′-bipiperidine-1...) Show SMILES CN1CCC(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 Show InChI InChI=1S/C32H33N5O/c1-35-16-12-25(13-17-35)26-14-18-36(19-15-26)32(38)28-8-6-24(7-9-28)29-10-11-31-34-21-30(37(31)22-29)27-4-2-23(20-33)3-5-27/h2-11,21-22,25-26H,12-19H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM375553 (4-(6-(4-(1′-methyl-4,4′-bipiperidine-1...) Show SMILES CN1CCC(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 Show InChI InChI=1S/C32H33N5O/c1-35-16-12-25(13-17-35)26-14-18-36(19-15-26)32(38)28-8-6-24(7-9-28)29-10-11-31-34-21-30(37(31)22-29)27-4-2-23(20-33)3-5-27/h2-11,21-22,25-26H,12-19H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...				J Med Chem 50: 3841-50 (2007) BindingDB Entry DOI: 10.7270/Q2XP777K
					More data for this Ligand-Target Pair