BDBM376046 4-chloro-N-[1-(4- fluorophenyl)-3-pyridin-4-yl- 1H-pyrazol-5-yl]-3-(1H- pyrazol-3-yl)benzamide::US9914736, Compound 42

SMILES: Fc1ccc(cc1)-n1nc(cc1NC(=O)c1ccc(Cl)c(c1)-c1cc[nH]n1)-c1ccncc1

InChI Key: InChIKey=ZMGIKDZTOLEKEH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376046 (4-chloro-N-[1-(4- fluorophenyl)-3-pyridin-4-yl- 1H...) Show SMILES Fc1ccc(cc1)-n1nc(cc1NC(=O)c1ccc(Cl)c(c1)-c1cc[nH]n1)-c1ccncc1 Show InChI InChI=1S/C24H16ClFN6O/c25-20-6-1-16(13-19(20)21-9-12-28-30-21)24(33)29-23-14-22(15-7-10-27-11-8-15)31-32(23)18-4-2-17(26)3-5-18/h1-14H,(H,28,30)(H,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair