BDBM376053 2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-phenyl-1H- pyrazol-4-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 49

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cn[nH]c2-c2ccccc2)c(Cl)cc1C(F)(F)F

InChI Key: InChIKey=MZJQIPZFNRINIX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376053 (2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-phenyl...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cn[nH]c2-c2ccccc2)c(Cl)cc1C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O/c1-30-8-7-17(29-30)13-9-14(16(22)10-15(13)21(23,24)25)20(31)27-18-11-26-28-19(18)12-5-3-2-4-6-12/h2-11H,1H3,(H,26,28)(H,27,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair