BDBM376055 N-[3-(hydroxymethyl)-5'- methyl-2'H-1,3'-bipyrazol-5- yl'-3-(1-methyl-1H-pyrazol-3- yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 51

SMILES: Cc1cc([nH]n1)-n1nc(CO)cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F

InChI Key: InChIKey=SHIOHBNZBAJSQC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376055 (N-[3-(hydroxymethyl)-5'- methyl-2'H-1,3'-bipyrazol...) Show SMILES Cc1cc([nH]n1)-n1nc(CO)cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F Show InChI InChI=1S/C20H18F3N7O2/c1-11-7-18(26-25-11)30-17(9-13(10-31)27-30)24-19(32)12-3-4-15(20(21,22)23)14(8-12)16-5-6-29(2)28-16/h3-9,31H,10H2,1-2H3,(H,24,32)(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair