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SMILES: Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cn2cnnn2)nn1-c1ccccc1

InChI Key: InChIKey=GJLPQYFTPOVFJG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376070   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM376070
PNG
(3-(1-methyl-1H-pyrazol-3-yl)- N-[1-phenyl-3-(1H-te...)
Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cn2cnnn2)nn1-c1ccccc1
Show InChI InChI=1S/C23H18F3N9O/c1-33-10-9-20(30-33)18-11-15(7-8-19(18)23(24,25)26)22(36)28-21-12-16(13-34-14-27-31-32-34)29-35(21)17-5-3-2-4-6-17/h2-12,14H,13H2,1H3,(H,28,36)
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



University of Namur



Assay Description
 In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...

J Med Chem 51: 3077-80 (2008)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair