BDBM377044 US10259818, Example 26

SMILES: C[C@H](c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)C(=O)OC(C)(C)C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=SIHWKUJEGPQWPY-AWKYBWMHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 377044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM377044 (US10259818, Example 26) Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)C(=O)OC(C)(C)C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C26H33ClFN7O3/c1-13-8-33(16-9-34(10-16)25(36)38-26(4,5)6)11-18-21(28)19(27)7-17(22(18)37-13)15(3)35-24-20(14(2)32-35)23(29)30-12-31-24/h7,12-13,15-16H,8-11H2,1-6H3,(H2,29,30,31)/t13?,15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description [γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2Q242JB
					More data for this Ligand-Target Pair