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BDBM377190 N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide::US10265307, Example 39::US10517858, Example 39::US10828290, Example 39

SMILES: C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

InChI Key: InChIKey=CXVCGOXRMUMGCU-KGLIPLIRSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 377190   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Curacyte Chemistry GmbH



Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


J Med Chem 49: 4116-26 (2006)


BindingDB Entry DOI: 10.7270/Q2FJ2K39
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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Curacyte Chemistry GmbH



Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


J Med Chem 49: 4116-26 (2006)


BindingDB Entry DOI: 10.7270/Q2FJ2K39
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Curacyte Chemistry GmbH



Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


J Med Chem 49: 4116-26 (2006)


BindingDB Entry DOI: 10.7270/Q2FJ2K39
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...


US Patent US10517858 (2019)


BindingDB Entry DOI: 10.7270/Q2XD1422
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...


US Patent US10517858 (2019)


BindingDB Entry DOI: 10.7270/Q2XD1422
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
US11229631, Example 39
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...


US Patent US10828290 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
US11229631, Example 39
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
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n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
US11229631, Example 39
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377190
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-2,3-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1c2CCOc2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.15,2.69,;-1.48,1.93,;-2.82,2.69,;-4.15,1.93,;-5.48,2.69,;-4.15,.38,;-2.82,-.38,;-1.48,.38,;-2.82,-1.93,;-4.15,-2.69,;-5.61,-2.22,;-6.52,-3.47,;-5.61,-4.71,;-4.15,-4.23,;-2.82,-5,;-1.48,-4.23,;-1.48,-2.69,;-.15,-1.93,;1.18,-2.69,;1.18,-4.23,;2.52,-1.93,;3.85,-2.69,;5.19,-1.93,;5.19,-.38,;6.52,.38,;3.85,.38,;2.52,-.38,;3.85,1.93,;2.52,2.7,;1.18,1.93,;2.52,4.24,;3.85,5,;5.19,4.24,;5.19,2.7,;6.52,1.93,)|
Show InChI InChI=1S/C25H24F3N5O2/c1-13-9-14(29)12-33(11-13)23-15-7-8-35-25(15)30-10-20(23)32-24(34)19-6-5-18(28)22(31-19)21-16(26)3-2-4-17(21)27/h2-6,10,13-14H,7-9,11-12,29H2,1H3,(H,32,34)/t13-,14+/m1/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...


US Patent US10517858 (2019)


BindingDB Entry DOI: 10.7270/Q2XD1422
More data for this
Ligand-Target Pair