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SMILES: COC(C1COC1)c1cc(Cl)c2CCN(Cc3c4ccn(C)c4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key:

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378912   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM378912
PNG
(5,8-dichloro-7-[methoxy(oxetan-3-yl)methyl]-2-[(7-...)
Show SMILES COC(C1COC1)c1cc(Cl)c2CCN(Cc3c4ccn(C)c4c(C)[nH]c3=O)C(=O)c2c1Cl
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...

J Med Chem 51: 4150-69 (2008)


BindingDB Entry DOI: 10.7270/Q2WM1GRX
More data for this
Ligand-Target Pair