null

SMILES: CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1

InChI Key: InChIKey=ARVDGBFKIFLARF-PMFMOCITSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 379839   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379839 (US9926281, Compound 269 | US9926281, Compound 446) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379839 (US9926281, Compound 269 | US9926281, Compound 446) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM379839 (US9926281, Compound 269 | US9926281, Compound 446) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM379839 (US9926281, Compound 269 | US9926281, Compound 446) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM379839 (US9926281, Compound 269 | US9926281, Compound 446) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM379839 (US9926281, Compound 269 | US9926281, Compound 446) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair