null
SMILES: COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CC(N)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1
InChI Key: InChIKey=XIJQHLBJFSYQQB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM381126![]() (3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon | Assay Description Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin... | J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM381126![]() (3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon | Assay Description Method 1: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining ... | J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM381126![]() (3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | >706 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon | Assay Description Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t... | J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM381126![]() (3-((4-((4-(3-(3-(2-Amino-2-oxoethyl)-5-(tert-butyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri... | J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N | |||||||||||
More data for this Ligand-Target Pair |