BDBM384464 US10590114, No. 151::US9932325, Example 150::US9932325, Example 151

SMILES: CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br

InChI Key: InChIKey=QEAXZAQDYNKCMP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 384464   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				Bioorg Med Chem Lett 18: 2567-73 (2008) BindingDB Entry DOI: 10.7270/Q29G5Q4M
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				Bioorg Med Chem Lett 18: 2567-73 (2008) BindingDB Entry DOI: 10.7270/Q29G5Q4M
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM384464 (US10590114, No. 151 | US11111235, Compound 150 | U...) Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair