BDBM392324 6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3-dichloropyridin-4-yl)thio)pyrazin-2-amine::US10301278, Example 43::US10301278, Example 49

SMILES: CC1(CN)CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1

InChI Key: InChIKey=SHTCSCWHCOLKRA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392324   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM392324 (6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3...) Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1 Show InChI InChI=1S/C16H20Cl2N6S/c1-16(9-19)3-6-24(7-4-16)11-8-22-15(14(20)23-11)25-10-2-5-21-13(18)12(10)17/h2,5,8H,3-4,6-7,9,19H2,1H3,(H2,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				J Med Chem 52: 1388-407 (2009) BindingDB Entry DOI: 10.7270/Q2N87D37
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM392324 (6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3...) Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1 Show InChI InChI=1S/C16H20Cl2N6S/c1-16(9-19)3-6-24(7-4-16)11-8-22-15(14(20)23-11)25-10-2-5-21-13(18)12(10)17/h2,5,8H,3-4,6-7,9,19H2,1H3,(H2,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				J Med Chem 52: 1388-407 (2009) BindingDB Entry DOI: 10.7270/Q2N87D37
					More data for this Ligand-Target Pair