BDBM392541 N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-3-(aminomethyl)-1-((3- chloroquinolin-6-yl)methyl)-1H- pyrazole-4-carboxamide::US10301284, Example 27::US10781200, Example 27

SMILES: Cc1cc(N)nc(C)c1CNC(=O)c1cn(Cc2ccc3ncc(Cl)cc3c2)nc1CN

InChI Key: InChIKey=MTEWYIIDBDKBQW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM392541 (N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-3-(a...) Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cn(Cc2ccc3ncc(Cl)cc3c2)nc1CN Show InChI InChI=1S/C23H24ClN7O/c1-13-5-22(26)29-14(2)18(13)10-28-23(32)19-12-31(30-21(19)8-25)11-15-3-4-20-16(6-15)7-17(24)9-27-20/h3-7,9,12H,8,10-11,25H2,1-2H3,(H2,26,29)(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ATTUNE PHARMACEUTICALS, INC. US Patent					Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...				US Patent US10781200 (2020)
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM392541 (N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-3-(a...) Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cn(Cc2ccc3ncc(Cl)cc3c2)nc1CN Show InChI InChI=1S/C23H24ClN7O/c1-13-5-22(26)29-14(2)18(13)10-28-23(32)19-12-31(30-21(19)8-25)11-15-3-4-20-16(6-15)7-17(24)9-27-20/h3-7,9,12H,8,10-11,25H2,1-2H3,(H2,26,29)(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2CV4M2H
					More data for this Ligand-Target Pair