BDBM392793 7-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-5-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-3H-benzimidazole-4-carboxamide methanesulfonic acid salt::US10301305, Example 210

SMILES: CN1CCC[C@@H]1COc1cc(-c2cnc3OCCCc3c2)c2nc[nH]c2c1C(N)=O

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 392793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D-alanine--D-alanyl carrier protein ligase (Staphylococcus aureus (strain SA113))	BDBM392793 (7-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-5-[[(...) Show SMILES CN1CCC[C@@H]1COc1cc(-c2cnc3OCCCc3c2)c2nc[nH]c2c1C(N)=O |r| Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair
D-alanine--D-alanyl carrier protein ligase (Streptococcus agalactiae serotype V (strain ATCC B...)	BDBM392793 (7-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-5-[[(...) Show SMILES CN1CCC[C@@H]1COc1cc(-c2cnc3OCCCc3c2)c2nc[nH]c2c1C(N)=O |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair
D-alanine--D-alanyl carrier protein ligase (Enterococcus faecium E1679)	BDBM392793 (7-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-5-[[(...) Show SMILES CN1CCC[C@@H]1COc1cc(-c2cnc3OCCCc3c2)c2nc[nH]c2c1C(N)=O |r| Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair
D-alanine--D-alanyl carrier protein ligase (Enterococcus faecalis (strain ATCC 700802 / V583))	BDBM392793 (7-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-5-[[(...) Show SMILES CN1CCC[C@@H]1COc1cc(-c2cnc3OCCCc3c2)c2nc[nH]c2c1C(N)=O |r| Show InChI	MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair