BDBM393431 N-(5-((2S,5R,6S,7R)-5-amino-6- methoxy-7-methyloxepan-2-yl)- 1-methyl-1H-pyrazol-4-yl)-2- (2,6-difluorophenyl)thiazole-4- carboxamide::US9963446, Example 118

SMILES: CO[C@H]1[C@H](N)CC[C@H](O[C@@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C

InChI Key: InChIKey=ZNMZBZGLWLFBPB-JURPJUOCSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM393431 (N-(5-((2S,5R,6S,7R)-5-amino-6- methoxy-7-methyloxe...) Show SMILES CO[C@H]1[C@H](N)CC[C@H](O[C@@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C22H25F2N5O3S/c1-11-20(31-3)14(25)7-8-17(32-11)19-15(9-26-29(19)2)27-21(30)16-10-33-22(28-16)18-12(23)5-4-6-13(18)24/h4-6,9-11,14,17,20H,7-8,25H2,1-3H3,(H,27,30)/t11-,14-,17+,20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q22B91B0
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