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BDBM393434 N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxepan-2-yl)-1- methyl-1H-pyrazol-4-yl)-2-(2,6- difluorophenyl)thiazole-4- carboxamide::US9963446, Example 121

SMILES: C[C@@H]1O[C@@H](CC[C@@H](N)[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C

InChI Key: InChIKey=HKRXJKSQNXPSLH-NOISCPHCSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393434   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM393434
PNG
(N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxep...)
Show SMILES C[C@@H]1O[C@@H](CC[C@@H](N)[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r|
Show InChI InChI=1S/C21H22F3N5O2S/c1-10-18(24)13(25)6-7-16(31-10)19-14(8-26-29(19)2)27-20(30)15-9-32-21(28-15)17-11(22)4-3-5-12(17)23/h3-5,8-10,13,16,18H,6-7,25H2,1-2H3,(H,27,30)/t10-,13+,16-,18-/m0/s1
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KEGG

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UniProtKB/TrEMBL

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
 0.00500n/an/an/an/an/an/an/an/a



Burnham Institute for Medical Research



Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...

Chem Biol Drug Des 71: 131-9 (2008)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair