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SMILES: CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12

InChI Key: InChIKey=WNBSKUWWSAYUGL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 396960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396960 (US10442810, Example 22 | US10844069, Example 22 | ...) Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair