null

SMILES: CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O

InChI Key: InChIKey=MIUFNUOBZNFJGF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 397018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair