null

SMILES: COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F

InChI Key: InChIKey=UZPGPNPHWOOVAT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 397373   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM397373 (US10596172, Compound I-328 | US10828300, Compound ...) Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2NV9MM2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM397373 (US10596172, Compound I-328 | US10828300, Compound ...) Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM397373 (US10596172, Compound I-328 | US10828300, Compound ...) Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM397373 (US10596172, Compound I-328 | US10828300, Compound ...) Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10828300 (2020) BindingDB Entry DOI: 10.7270/Q2JS9THK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM397373 (US10596172, Compound I-328 | US10828300, Compound ...) Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM397373 (US10596172, Compound I-328 | US10828300, Compound ...) Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair