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BDBM397408 US9987278, Compound Reference 18

SMILES: CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)\C=C\CN(C)C

InChI Key: InChIKey=DYBTVIIFUJPFPB-BQYQJAHWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 397408   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
FLT3(D835Y)


(Homo sapiens (Human))		BDBM397408
PNG
(US9987278, Compound Reference 18)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C28H43N9O3/c1-5-13-30-26-23(19-34-28(36-26)32-16-11-21-9-14-29-15-10-21)27(40)31-17-12-22(6-2)35-25(39)20-33-24(38)8-7-18-37(3)4/h7-10,14-15,19,22H,5-6,11-13,16-18,20H2,1-4H3,(H,31,40)(H,33,38)(H,35,39)(H2,30,32,34,36)/b8-7+
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n/an/a<1n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair