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SMILES: CCCc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1

InChI Key: InChIKey=KTEJRLZXDCYYSX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398282   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398282
PNG
(US10323018, Compound I-16)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN5O/c1-2-4-20-19-11-8-17(24(31)28-12-3-5-22-26-13-14-27-22)15-21(19)30-23(29-20)16-6-9-18(25)10-7-16/h6-11,13-15H,2-5,12H2,1H3,(H,26,27)(H,28,31)
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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair