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SMILES: CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cnn[nH]1)-c1ccc(F)cc1

InChI Key: InChIKey=SBJIJVFCRAWXAD-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398386   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398386
PNG
(US10323018, Compound I-115)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cnn[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H22FN5O2/c1-2-31-22-13-20(15-5-8-17(24)9-6-15)27-21-12-16(7-10-19(21)22)23(30)25-11-3-4-18-14-26-29-28-18/h5-10,12-14H,2-4,11H2,1H3,(H,25,30)(H,26,28,29)
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MMDB

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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair