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SMILES: CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccnc(OC)c1

InChI Key: InChIKey=JYYZRRZUFXVLLO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398465   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398465
PNG
(US10323018, Compound I-194)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccnc(OC)c1
Show InChI InChI=1S/C25H22N6O3/c1-3-34-22-12-19(15-6-9-27-24(11-15)33-2)29-20-10-16(4-5-17(20)22)25(32)28-14-23-30-18-7-8-26-13-21(18)31-23/h4-13H,3,14H2,1-2H3,(H,28,32)(H,30,31)
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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair