null

SMILES: Brc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N

InChI Key: InChIKey=RRYCDJCSQSCPRC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 400580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400580 (US11285140, Example 336 | US9999619, Example 336) Show SMILES Brc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N Show InChI InChI=1S/C28H24Br2N8O/c29-21-9-18(10-22(30)11-21)27(39)36-7-2-23(3-8-36)37-16-28(17-37,4-5-31)38-15-20(14-35-38)25-19(12-32)13-34-26-24(25)1-6-33-26/h1,6,9-11,13-15,23H,2-4,7-8,16-17H2,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				Bioorg Med Chem 16: 4883-907 (2008) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400580 (US11285140, Example 336 | US9999619, Example 336) Show SMILES Brc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N Show InChI InChI=1S/C28H24Br2N8O/c29-21-9-18(10-22(30)11-21)27(39)36-7-2-23(3-8-36)37-16-28(17-37,4-5-31)38-15-20(14-35-38)25-19(12-32)13-34-26-24(25)1-6-33-26/h1,6,9-11,13-15,23H,2-4,7-8,16-17H2,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2DZ0CJQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400580 (US11285140, Example 336 | US9999619, Example 336) Show SMILES Brc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N Show InChI InChI=1S/C28H24Br2N8O/c29-21-9-18(10-22(30)11-21)27(39)36-7-2-23(3-8-36)37-16-28(17-37,4-5-31)38-15-20(14-35-38)25-19(12-32)13-34-26-24(25)1-6-33-26/h1,6,9-11,13-15,23H,2-4,7-8,16-17H2,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DZ0CJQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human))	BDBM400580 (US11285140, Example 336 | US9999619, Example 336) Show SMILES Brc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N Show InChI InChI=1S/C28H24Br2N8O/c29-21-9-18(10-22(30)11-21)27(39)36-7-2-23(3-8-36)37-16-28(17-37,4-5-31)38-15-20(14-35-38)25-19(12-32)13-34-26-24(25)1-6-33-26/h1,6,9-11,13-15,23H,2-4,7-8,16-17H2,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...				Bioorg Med Chem 16: 4883-907 (2008) BindingDB Entry DOI: 10.7270/Q2C82CNM
					More data for this Ligand-Target Pair