null

SMILES: FC(CCn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F

InChI Key: InChIKey=XIIBKTDLMRHHAQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 405078   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405078 (1-{2-fluoro-4-[4-({[6- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H21F8N9O3/c26-15(6-7-41-12-19(37-39-41)23(44)35-10-16-2-1-3-21(36-16)24(28,29)30)11-42-13-20(38-40-42)22(43)34-9-14-8-17(4-5-18(14)27)45-25(31,32)33/h1-5,8,12-13,15H,6-7,9-11H2,(H,34,43)(H,35,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76GP
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM405078 (1-{2-fluoro-4-[4-({[6- (trifluoromethyl)pyridin-2-...) Show SMILES FC(CCn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F Show InChI InChI=1S/C25H21F8N9O3/c26-15(6-7-41-12-19(37-39-41)23(44)35-10-16-2-1-3-21(36-16)24(28,29)30)11-42-13-20(38-40-42)22(43)34-9-14-8-17(4-5-18(14)27)45-25(31,32)33/h1-5,8,12-13,15H,6-7,9-11H2,(H,34,43)(H,35,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas System US Patent					Assay Description The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...				US Patent US10344025 (2019) BindingDB Entry DOI: 10.7270/Q2765HQC
					More data for this Ligand-Target Pair