null

SMILES: FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CCCOC2)cc1

InChI Key: InChIKey=MPEQBFXQQMVCCS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 408987   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM408987 (US10377744, Compound No. 8 | US11123311, Compound ...) Show SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CCCOC2)cc1 Show InChI InChI=1S/C19H24F3N3O4/c20-19(21,22)29-16-5-3-14(4-6-16)23-18(27)24-15-7-9-25(10-8-15)17(26)13-2-1-11-28-12-13/h3-6,13,15H,1-2,7-12H2,(H2,23,24,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eicosis, LLC US Patent					Assay Description FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...				US Patent US10377744 (2019) BindingDB Entry DOI: 10.7270/Q2N3009K
					More data for this Ligand-Target Pair
Epoxide hydrolase 1 (Homo sapiens (Human))	BDBM408987 (US10377744, Compound No. 8 | US11123311, Compound ...) Show SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CCCOC2)cc1 Show InChI InChI=1S/C19H24F3N3O4/c20-19(21,22)29-16-5-3-14(4-6-16)23-18(27)24-15-7-9-25(10-8-15)17(26)13-2-1-11-28-12-13/h3-6,13,15H,1-2,7-12H2,(H2,23,24,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		1.99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2HH6Q63
					More data for this Ligand-Target Pair
Bifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM408987 (US10377744, Compound No. 8 | US11123311, Compound ...) Show SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CCCOC2)cc1 Show InChI InChI=1S/C19H24F3N3O4/c20-19(21,22)29-16-5-3-14(4-6-16)23-18(27)24-15-7-9-25(10-8-15)17(26)13-2-1-11-28-12-13/h3-6,13,15H,1-2,7-12H2,(H2,23,24,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Q81H7M
					More data for this Ligand-Target Pair
Bifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM408987 (US10377744, Compound No. 8 | US11123311, Compound ...) Show SMILES FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CCCOC2)cc1 Show InChI InChI=1S/C19H24F3N3O4/c20-19(21,22)29-16-5-3-14(4-6-16)23-18(27)24-15-7-9-25(10-8-15)17(26)13-2-1-11-28-12-13/h3-6,13,15H,1-2,7-12H2,(H2,23,24,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115735 BindingDB Entry DOI: 10.7270/Q2SF30T4
					More data for this Ligand-Target Pair