null
SMILES: F[C@H]1C[C@@H](N(C1)c1nc2c(cnn2cc1F)C#N)c1cncc(F)c1
InChI Key: InChIKey=UVWMNONKVVQRFQ-GXTWGEPZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM410187 (6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM410187 (6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
BLUEPRINT MEDICINES CORPORATION US Patent | Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1... | US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5 | |||||||||||
More data for this Ligand-Target Pair |