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SMILES: F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cc(c1)C(=O)NCC1CC1

InChI Key: InChIKey=BODWRZMHRIBSBB-RBUKOAKNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 410202   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410202 (US10370379, Compound 19 | US11059827, Compound 19) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cc(c1)C(=O)NCC1CC1 |r| Show InChI InChI=1S/C22H20F2N6O/c23-17-6-14(5-15(7-17)22(31)26-10-13-1-2-13)19-8-18(24)12-29(19)20-3-4-30-21(28-20)16(9-25)11-27-30/h3-7,11,13,18-19H,1-2,8,10,12H2,(H,26,31)/t18-,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410202 (US10370379, Compound 19 | US11059827, Compound 19) Show SMILES F[C@H]1C[C@@H](N(C1)c1ccn2ncc(C#N)c2n1)c1cc(F)cc(c1)C(=O)NCC1CC1 |r| Show InChI InChI=1S/C22H20F2N6O/c23-17-6-14(5-15(7-17)22(31)26-10-13-1-2-13)19-8-18(24)12-29(19)20-3-4-30-21(28-20)16(9-25)11-27-30/h3-7,11,13,18-19H,1-2,8,10,12H2,(H,26,31)/t18-,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair