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SMILES: CNC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1

InChI Key: InChIKey=GANQIESHYOHLTP-JKSUJKDBSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 410203   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410203 (US10370379, Compound 20 | US11059827, Compound 20) Show SMILES CNC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1 |r| Show InChI InChI=1S/C19H16F2N6O/c1-23-19(28)12-4-11(5-14(20)6-12)16-7-15(21)10-26(16)17-2-3-27-18(25-17)13(8-22)9-24-27/h2-6,9,15-16H,7,10H2,1H3,(H,23,28)/t15-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM410203 (US10370379, Compound 20 | US11059827, Compound 20) Show SMILES CNC(=O)c1cc(F)cc(c1)[C@H]1C[C@H](F)CN1c1ccn2ncc(C#N)c2n1 |r| Show InChI InChI=1S/C19H16F2N6O/c1-23-19(28)12-4-11(5-14(20)6-12)16-7-15(21)10-26(16)17-2-3-27-18(25-17)13(8-22)9-24-27/h2-6,9,15-16H,7,10H2,1H3,(H,23,28)/t15-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...				US Patent US10370379 (2019) BindingDB Entry DOI: 10.7270/Q2TM7DG5
					More data for this Ligand-Target Pair