BDBM411520 (R)-((2-(1H- benzo[d]imidazol-1-yl)- 6-(3-methylmorpholino)- pyrimidin-4-yl)imino)- dimethyl-lambda6-sulfanone::US10392376, Example 71::US10800769, Example 71

SMILES: C[C@@H]1COCCN1c1cc(N=S(C)(C)=O)nc(n1)-n1cnc2ccccc12

InChI Key: InChIKey=XTXRQWYMRAMWQP-CYBMUJFWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 411520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATR/ATRIP (Homo sapiens (Human))	BDBM411520 ((R)-((2-(1H- benzo[d]imidazol-1-yl)- 6-(3-methylmo...) Show SMILES C[C@@H]1COCCN1c1cc(N=S(C)(C)=O)nc(n1)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C18H22N6O2S/c1-13-11-26-9-8-23(13)17-10-16(22-27(2,3)25)20-18(21-17)24-12-19-14-6-4-5-7-15(14)24/h4-7,10,12-13H,8-9,11H2,1-3H3/t13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...				US Patent US10392376 (2019) BindingDB Entry DOI: 10.7270/Q2H70J60
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM411520 ((R)-((2-(1H- benzo[d]imidazol-1-yl)- 6-(3-methylmo...) Show SMILES C[C@@H]1COCCN1c1cc(N=S(C)(C)=O)nc(n1)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C18H22N6O2S/c1-13-11-26-9-8-23(13)17-10-16(22-27(2,3)25)20-18(21-17)24-12-19-14-6-4-5-7-15(14)24/h4-7,10,12-13H,8-9,11H2,1-3H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; ChemPartner Corporation US Patent					Assay Description Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...				US Patent US10800769 (2020)
					More data for this Ligand-Target Pair
ATR/ATRIP (Homo sapiens (Human))	BDBM411520 ((R)-((2-(1H- benzo[d]imidazol-1-yl)- 6-(3-methylmo...) Show SMILES C[C@@H]1COCCN1c1cc(N=S(C)(C)=O)nc(n1)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C18H22N6O2S/c1-13-11-26-9-8-23(13)17-10-16(22-27(2,3)25)20-18(21-17)24-12-19-14-6-4-5-7-15(14)24/h4-7,10,12-13H,8-9,11H2,1-3H3/t13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; ChemPartner Corporation US Patent					Assay Description Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...				US Patent US10800769 (2020)
					More data for this Ligand-Target Pair