BDBM416565 3-(4-amino-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2,2-dimethylpropan-1-ol::US10307425, Example 32::US10632122, Example 32
SMILES: CCOc1ccc2cc(ccc2c1)-c1nn(CC(C)(C)CO)c2ncnc(N)c12
InChI Key: InChIKey=FSWBNBURNIHVHB-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calmodulin-domain protein kinase 1 (Toxoplasma gondii) | BDBM416565![]() (3-(4-amino-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington US Patent | Assay Description Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ... | US Patent US10632122 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CAM kinase, CDPK family TgCDPK1 (Toxoplasma gondii (strain ATCC 50861 / VEG)) | BDBM416565![]() (3-(4-amino-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington US Patent | Assay Description Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ... | US Patent US10307425 (2019) BindingDB Entry DOI: 10.7270/Q2862JT9 | |||||||||||
More data for this Ligand-Target Pair |