BDBM418852 N-[2-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5- (trifluoromethyl)pyrimidin-4- yl]amino}methyl)pyridin-3-yl]-N- methylmethane-sulfonamide (352), hydrochloride salt::US10450297, Example 352
SMILES: C[C@@H](N)c1ccc(Nc2ncc(c(NCc3ncccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
InChI Key: InChIKey=RRPARVPNVHUBQG-CYBMUJFWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Focal adhesion kinase 1 [410-689] (Homo sapiens (Human)) | BDBM418852![]() (N-[2-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.595 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2T72KQP | |||||||||||
More data for this Ligand-Target Pair |