null

SMILES: Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1

InChI Key: InChIKey=VORVEMPBDAPGDR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 421488   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	652	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	652	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair