null
SMILES: CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-n1ccccc1=O
InChI Key: InChIKey=QWLSZCGELBETJN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Apelin receptor (Homo sapiens (Human)) | BDBM422180![]() (2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-[4-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ... | US Patent US10508104 (2019) BindingDB Entry DOI: 10.7270/Q21838WS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Mus musculus) | BDBM422180![]() (2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-[4-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Rattus norvegicus) | BDBM422180![]() (2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-[4-(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM422180![]() (2-butyl-1-(2,6- dimethoxyphenyl)-6- hydroxy-5-[4-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 | |||||||||||
More data for this Ligand-Target Pair |