BDBM423285 US10501451, Example 11, P-1::US10501451, Example 11, P-2::US10954225, Example 11,P-2

SMILES: Cc1ccc(CN2OCCC(N3CCC(C(F)C3)c3ccc(O)c(F)c3)C2=O)cc1

InChI Key: InChIKey=RWWRVFJUUHSBLX-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423285   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423285 (US10501451, Example 11, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCCC(N3CCC(C(F)C3)c3ccc(O)c(F)c3)C2=O)cc1 Show InChI InChI=1S/C23H26F2N2O3/c1-15-2-4-16(5-3-15)13-27-23(29)21(9-11-30-27)26-10-8-18(20(25)14-26)17-6-7-22(28)19(24)12-17/h2-7,12,18,20-21,28H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.06	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...				US Patent US10954225 (2021)
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423285 (US10501451, Example 11, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCCC(N3CCC(C(F)C3)c3ccc(O)c(F)c3)C2=O)cc1 Show InChI InChI=1S/C23H26F2N2O3/c1-15-2-4-16(5-3-15)13-27-23(29)21(9-11-30-27)26-10-8-18(20(25)14-26)17-6-7-22(28)19(24)12-17/h2-7,12,18,20-21,28H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.06	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...				US Patent US10501451 (2019) BindingDB Entry DOI: 10.7270/Q2GB26FG
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423285 (US10501451, Example 11, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCCC(N3CCC(C(F)C3)c3ccc(O)c(F)c3)C2=O)cc1 Show InChI InChI=1S/C23H26F2N2O3/c1-15-2-4-16(5-3-15)13-27-23(29)21(9-11-30-27)26-10-8-18(20(25)14-26)17-6-7-22(28)19(24)12-17/h2-7,12,18,20-21,28H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	39.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...				US Patent US10954225 (2021)
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423285 (US10501451, Example 11, P-1 | US10501451, Example ...) Show SMILES Cc1ccc(CN2OCCC(N3CCC(C(F)C3)c3ccc(O)c(F)c3)C2=O)cc1 Show InChI InChI=1S/C23H26F2N2O3/c1-15-2-4-16(5-3-15)13-27-23(29)21(9-11-30-27)26-10-8-18(20(25)14-26)17-6-7-22(28)19(24)12-17/h2-7,12,18,20-21,28H,8-11,13-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	39.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...				US Patent US10501451 (2019) BindingDB Entry DOI: 10.7270/Q2GB26FG
					More data for this Ligand-Target Pair