BDBM423291 US10501451, Example 14, P-1::US10501451, Example 14, P-2::US10954225, Example 14,P-2

SMILES: Oc1ccc(cc1F)C1CCN(CC1F)C1CCON(Cc2ccc(Cl)cc2)C1=O

InChI Key: InChIKey=IHWNSMGEPWAHER-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423291   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423291 (US10501451, Example 14, P-1 | US10501451, Example ...) Show SMILES Oc1ccc(cc1F)C1CCN(CC1F)C1CCON(Cc2ccc(Cl)cc2)C1=O Show InChI InChI=1S/C22H23ClF2N2O3/c23-16-4-1-14(2-5-16)12-27-22(29)20(8-10-30-27)26-9-7-17(19(25)13-26)15-3-6-21(28)18(24)11-15/h1-6,11,17,19-20,28H,7-10,12-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...				US Patent US10501451 (2019) BindingDB Entry DOI: 10.7270/Q2GB26FG
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423291 (US10501451, Example 14, P-1 | US10501451, Example ...) Show SMILES Oc1ccc(cc1F)C1CCN(CC1F)C1CCON(Cc2ccc(Cl)cc2)C1=O Show InChI InChI=1S/C22H23ClF2N2O3/c23-16-4-1-14(2-5-16)12-27-22(29)20(8-10-30-27)26-9-7-17(19(25)13-26)15-3-6-21(28)18(24)11-15/h1-6,11,17,19-20,28H,7-10,12-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...				US Patent US10954225 (2021)
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423291 (US10501451, Example 14, P-1 | US10501451, Example ...) Show SMILES Oc1ccc(cc1F)C1CCN(CC1F)C1CCON(Cc2ccc(Cl)cc2)C1=O Show InChI InChI=1S/C22H23ClF2N2O3/c23-16-4-1-14(2-5-16)12-27-22(29)20(8-10-30-27)26-9-7-17(19(25)13-26)15-3-6-21(28)18(24)11-15/h1-6,11,17,19-20,28H,7-10,12-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	98.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...				US Patent US10954225 (2021)
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM423291 (US10501451, Example 14, P-1 | US10501451, Example ...) Show SMILES Oc1ccc(cc1F)C1CCN(CC1F)C1CCON(Cc2ccc(Cl)cc2)C1=O Show InChI InChI=1S/C22H23ClF2N2O3/c23-16-4-1-14(2-5-16)12-27-22(29)20(8-10-30-27)26-9-7-17(19(25)13-26)15-3-6-21(28)18(24)11-15/h1-6,11,17,19-20,28H,7-10,12-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	98.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...				US Patent US10501451 (2019) BindingDB Entry DOI: 10.7270/Q2GB26FG
					More data for this Ligand-Target Pair