null

SMILES: CC[C@H](C)[C@H](NC(=O)c1ccc(CNC(=O)c2[nH]c3c(cccc3c2CCCOc2cc(C)c(Cl)c(C)c2)-c2c(C)nn(C)c2C)o1)C(O)=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 429155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM429155 (US10533010, Example I-270 | US11208415, Example I-...) Show SMILES CC[C@H](C)[C@H](NC(=O)c1ccc(CNC(=O)c2[nH]c3c(cccc3c2CCCOc2cc(C)c(Cl)c(C)c2)-c2c(C)nn(C)c2C)o1)C(O)=O |r,wU:4.4,2.2,(-13.88,5.68,;-12.64,6.59,;-11.23,5.96,;-11.07,4.43,;-9.98,6.87,;-8.58,6.24,;-7.33,7.15,;-7.49,8.68,;-5.92,6.52,;-4.59,7.29,;-3.45,6.26,;-4.07,4.85,;-3.3,3.52,;-1.76,3.52,;-.99,2.19,;-1.76,.85,;.55,2.19,;1.45,3.43,;2.92,2.96,;4.25,3.73,;5.59,2.96,;5.59,1.42,;4.25,.65,;2.92,1.42,;1.45,.94,;.98,-.52,;2.01,-1.67,;1.53,-3.13,;2.56,-4.28,;2.09,-5.74,;.58,-6.06,;.1,-7.53,;-1.4,-7.85,;1.13,-8.67,;.66,-10.14,;2.64,-8.35,;3.67,-9.5,;3.12,-6.89,;4.25,5.27,;3.01,6.17,;1.54,5.7,;3.48,7.64,;5.02,7.64,;5.93,8.88,;5.5,6.17,;6.96,5.7,;-5.6,5.01,;-10.14,8.4,;-8.9,9.31,;-11.55,9.03,)| Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		<50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM429155 (US10533010, Example I-270 | US11208415, Example I-...) Show SMILES CC[C@H](C)[C@H](NC(=O)c1ccc(CNC(=O)c2[nH]c3c(cccc3c2CCCOc2cc(C)c(Cl)c(C)c2)-c2c(C)nn(C)c2C)o1)C(O)=O |r,wU:4.4,2.2,(-13.88,5.68,;-12.64,6.59,;-11.23,5.96,;-11.07,4.43,;-9.98,6.87,;-8.58,6.24,;-7.33,7.15,;-7.49,8.68,;-5.92,6.52,;-4.59,7.29,;-3.45,6.26,;-4.07,4.85,;-3.3,3.52,;-1.76,3.52,;-.99,2.19,;-1.76,.85,;.55,2.19,;1.45,3.43,;2.92,2.96,;4.25,3.73,;5.59,2.96,;5.59,1.42,;4.25,.65,;2.92,1.42,;1.45,.94,;.98,-.52,;2.01,-1.67,;1.53,-3.13,;2.56,-4.28,;2.09,-5.74,;.58,-6.06,;.1,-7.53,;-1.4,-7.85,;1.13,-8.67,;.66,-10.14,;2.64,-8.35,;3.67,-9.5,;3.12,-6.89,;4.25,5.27,;3.01,6.17,;1.54,5.7,;3.48,7.64,;5.02,7.64,;5.93,8.88,;5.5,6.17,;6.96,5.7,;-5.6,5.01,;-10.14,8.4,;-8.9,9.31,;-11.55,9.03,)| Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...				US Patent US10533010 (2020) BindingDB Entry DOI: 10.7270/Q2T72KVG
					More data for this Ligand-Target Pair