BDBM429694 5-methyl-5-(2- methyl-3-oxo- 3-(4-m- tolylpiperidin- yl)propyl) imidazolidine- 2,4-dione::US10550100, Compound 27
SMILES: C[C@@H](C[C@@]1(C)NC(=O)NC1=O)C(=O)N1CCC(CC1)c1cccc(C)c1
InChI Key: InChIKey=DLWUUXWPNZKTFO-VBKZILBWSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ADAMTS5 (Rattus norvegicus (Rat)) | BDBM429694 (5-methyl-5-(2- methyl-3-oxo- 3-(4-m- tolylpiperidi...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 37.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H).For the d... | US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human)) | BDBM429694 (5-methyl-5-(2- methyl-3-oxo- 3-(4-m- tolylpiperidi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 37.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res... | US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM429694 (5-methyl-5-(2- methyl-3-oxo- 3-(4-m- tolylpiperidi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th... | US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM429694 (5-methyl-5-(2- methyl-3-oxo- 3-(4-m- tolylpiperidi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC... | US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human) | BDBM429694 (5-methyl-5-(2- methyl-3-oxo- 3-(4-m- tolylpiperidi...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 37.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GALAPAGOS NV US Patent | Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-... | US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N | |||||||||||
More data for this Ligand-Target Pair |