BDBM443432 Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]ethoxy}phenyl)-7- (trifluoromethyl)-5H- [1]benzopyrano[4,3- c]quinolin-2-ol::US10654866, Example 2
SMILES: Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
InChI Key: InChIKey=BGOOMSGEXIBXHQ-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estrogen receptor (Homo sapiens (Human)) | BDBM443432![]() (Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 2.17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM443432![]() (Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | 2.17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT... | US Patent US10654866 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor alpha Y537S (Homo sapiens (Human)) | BDBM443432![]() (Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 6.78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor alpha Y537S (Homo sapiens (Human)) | BDBM443432![]() (Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...) | PDB GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | 6.78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT... | US Patent US10654866 (2020) | |||||||||||
More data for this Ligand-Target Pair |