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SMILES: COCCn1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1

InChI Key: InChIKey=OFSMVCPTJBHXSJ-MAUKXSAKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447693   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM447693
PNG
(US10689367, Example 12.0)
Show SMILES COCCn1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1 |r|
Show InChI InChI=1S/C21H28ClN7O4S/c1-13(2)33-18(19-24-11-17(22)12-25-19)15(4)34(30,31)28-21-27-26-20(29(21)6-7-32-5)16-8-14(3)9-23-10-16/h8-13,15,18H,6-7H2,1-5H3,(H,27,28)/t15-,18+/m0/s1
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US Patent
n/an/an/an/a 120n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10689367 (2020)


BindingDB Entry DOI: 10.7270/Q2P84FXK
More data for this
Ligand-Target Pair