null

SMILES: CO[C@H]1CN([C@@H]1C)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2

InChI Key: InChIKey=ZCJKTJJRRJIWRO-DZUOBACFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 449637   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449637 (US10703733, Example 250 | US10988451, Example 250) Show SMILES CO[C@H]1CN([C@@H]1C)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-7-5-9-33(47-3)30-13-10-28(30)19-42-22-38(16-6-8-26-17-29(39)12-14-31(26)38)23-49-34-15-11-27(18-32(34)42)36(44)40-50(46,21-24)41-37(45)43-20-35(48-4)25(43)2/h5,9,11-12,14-15,17-18,24-25,28,30,33,35H,6-8,10,13,16,19-23H2,1-4H3,(H,40,41,44,45,46)/b9-5+/t24-,25+,28-,30+,33-,35-,38-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021)
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449637 (US10703733, Example 250 | US10988451, Example 250) Show SMILES CO[C@H]1CN([C@@H]1C)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-7-5-9-33(47-3)30-13-10-28(30)19-42-22-38(16-6-8-26-17-29(39)12-14-31(26)38)23-49-34-15-11-27(18-32(34)42)36(44)40-50(46,21-24)41-37(45)43-20-35(48-4)25(43)2/h5,9,11-12,14-15,17-18,24-25,28,30,33,35H,6-8,10,13,16,19-23H2,1-4H3,(H,40,41,44,45,46)/b9-5+/t24-,25+,28-,30+,33-,35-,38-,50-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...				US Patent US10703733 (2020)
					More data for this Ligand-Target Pair