null

SMILES: COc1nc(C)c2nc(-c3cncc(c3)C#N)n(Cc3ccc(OC4CN5CCC4CC5)cc3F)c2n1

InChI Key: InChIKey=BFOQXVHYTNMZBZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM450136 (US10703755, Example 322) Show SMILES COc1nc(C)c2nc(-c3cncc(c3)C#N)n(Cc3ccc(OC4CN5CCC4CC5)cc3F)c2n1 |(-8.92,.3,;-7.74,-.69,;-6.41,.08,;-6.41,1.62,;-5.07,2.39,;-5.07,3.93,;-3.74,1.62,;-2.27,2.1,;-1.37,.85,;.17,.85,;.94,-.48,;2.48,-.48,;3.25,.85,;2.55,2.25,;.94,2.19,;3.34,3.57,;4.12,4.9,;-2.27,-.39,;-1.88,-1.88,;-.39,-2.28,;.7,-1.19,;2.19,-1.59,;2.59,-3.08,;4.07,-3.47,;5.16,-2.39,;4.76,-.9,;5.85,.19,;7.34,-.21,;7.74,-1.69,;6.65,-2.78,;6.65,-1.24,;5.85,-1.35,;1.5,-4.16,;.01,-3.77,;-1.08,-4.85,;-3.74,.08,;-5.07,-.69,)| Show InChI InChI=1S/C27H26FN7O2/c1-16-24-26(33-27(31-16)36-2)35(25(32-24)20-9-17(11-29)12-30-13-20)14-19-3-4-21(10-22(19)28)37-23-15-34-7-5-18(23)6-8-34/h3-4,9-10,12-13,18,23H,5-8,14-15H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent					Assay Description As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...				US Patent US10703755 (2020)
					More data for this Ligand-Target Pair