BDBM450968 8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,5-c]pyrimidine-1-carbonitrile::US10676479, Example 5

SMILES: Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C#N)c23)n(C)n1

InChI Key: InChIKey=YJHCUUIBUCMIFB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 450968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human))	BDBM450968 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...) Show SMILES Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C#N)c23)n(C)n1 Show InChI InChI=1S/C21H18FN7O/c1-12-7-18(28(2)27-12)15-10-25-21(29-11-26-17(8-23)20(15)29)24-9-14-13-5-6-30-19(13)4-3-16(14)22/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...				US Patent US10676479 (2020)
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human))	BDBM450968 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...) Show SMILES Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C#N)c23)n(C)n1 Show InChI InChI=1S/C21H18FN7O/c1-12-7-18(28(2)27-12)15-10-25-21(29-11-26-17(8-23)20(15)29)24-9-14-13-5-6-30-19(13)4-3-16(14)22/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...				US Patent US10676479 (2020)
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human))	BDBM450968 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...) Show SMILES Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnc(C#N)c23)n(C)n1 Show InChI InChI=1S/C21H18FN7O/c1-12-7-18(28(2)27-12)15-10-25-21(29-11-26-17(8-23)20(15)29)24-9-14-13-5-6-30-19(13)4-3-16(14)22/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...				US Patent US10676479 (2020)
					More data for this Ligand-Target Pair