Found 4 hits for monomerid = 462109 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM462109
(US10766884, Example A26 | US11220494, Example A26)Show SMILES CC1(C)OCCn2nc3c(F)cc(cc3c12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C22H26ClFN6O4S/c1-22(2)20-13-8-12(9-15(24)19(13)28-30(20)6-7-34-22)18-14(23)10-25-21(27-18)26-16-4-5-29(11-17(16)31)35(3,32)33/h8-10,16-17,31H,4-7,11H2,1-3H3,(H,25,26,27)/t16-,17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description
CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ... |
US Patent US10766884 (2020)
BindingDB Entry DOI: 10.7270/Q23F4SQG |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM462109
(US10766884, Example A26 | US11220494, Example A26)Show SMILES CC1(C)OCCn2nc3c(F)cc(cc3c12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C22H26ClFN6O4S/c1-22(2)20-13-8-12(9-15(24)19(13)28-30(20)6-7-34-22)18-14(23)10-25-21(27-18)26-16-4-5-29(11-17(16)31)35(3,32)33/h8-10,16-17,31H,4-7,11H2,1-3H3,(H,25,26,27)/t16-,17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2XG9V9M |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human)) | BDBM462109
(US10766884, Example A26 | US11220494, Example A26)Show SMILES CC1(C)OCCn2nc3c(F)cc(cc3c12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C22H26ClFN6O4S/c1-22(2)20-13-8-12(9-15(24)19(13)28-30(20)6-7-34-22)18-14(23)10-25-21(27-18)26-16-4-5-29(11-17(16)31)35(3,32)33/h8-10,16-17,31H,4-7,11H2,1-3H3,(H,25,26,27)/t16-,17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2XG9V9M |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human)) | BDBM462109
(US10766884, Example A26 | US11220494, Example A26)Show SMILES CC1(C)OCCn2nc3c(F)cc(cc3c12)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl |r| Show InChI InChI=1S/C22H26ClFN6O4S/c1-22(2)20-13-8-12(9-15(24)19(13)28-30(20)6-7-34-22)18-14(23)10-25-21(27-18)26-16-4-5-29(11-17(16)31)35(3,32)33/h8-10,16-17,31H,4-7,11H2,1-3H3,(H,25,26,27)/t16-,17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description
CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo... |
US Patent US10766884 (2020)
BindingDB Entry DOI: 10.7270/Q23F4SQG |
More data for this
Ligand-Target Pair | |
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