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SMILES: Cn1cc(cn1)-c1cc(ccc1F)-n1c(Cl)cc2c1ncn(CC1(O)CCN(CC1)C(=O)C1(C)CC1)c2=O

InChI Key: InChIKey=QOBNSAPTBBWVAY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 462621   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))		BDBM462621
PNG
(US10766903, Example 233)
Show SMILES Cn1cc(cn1)-c1cc(ccc1F)-n1c(Cl)cc2c1ncn(CC1(O)CCN(CC1)C(=O)C1(C)CC1)c2=O
Show InChI InChI=1S/C27H28ClFN6O3/c1-26(5-6-26)25(37)33-9-7-27(38,8-10-33)15-34-16-30-23-20(24(34)36)12-22(28)35(23)18-3-4-21(29)19(11-18)17-13-31-32(2)14-17/h3-4,11-14,16,38H,5-10,15H2,1-2H3
PDB
MMDB

KEGG

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PC cid
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US Patent
n/an/a<250n/an/an/an/an/an/a



ALMAC DISCOVERY LIMITED

US Patent


Assay Description
USP7 activity was monitored in a fluorescence polarisation (FP) homogeneous assay using the isopeptide ubiquitin-Lys-TAMRA substrate (U-558, Boston B...

US Patent US10766903 (2020)

More data for this
Ligand-Target Pair