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SMILES: Nc1ccc(nc1NC(=O)N1Cc2cnc(cc2C1)C(F)F)-c1cccnc1

InChI Key: InChIKey=IODXLLVFYQYBMT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 465380   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 2 (Homo sapiens (Human))	BDBM465380 (US10793567, Compound 16 | US11225479, Compound 16) Show SMILES Nc1ccc(nc1NC(=O)N1Cc2cnc(cc2C1)C(F)F)-c1cccnc1 Show InChI InChI=1S/C19H16F2N6O/c20-17(21)16-6-12-9-27(10-13(12)8-24-16)19(28)26-18-14(22)3-4-15(25-18)11-2-1-5-23-7-11/h1-8,17H,9-10,22H2,(H,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rodin Therapeutics, Inc. US Patent					Assay Description The following describes an assay protocol for measuring the deacetylation of a peptide substrate by the enzymes HDAC2 or HDAC1. Enzyme, substrate, an...				US Patent US10793567 (2020) BindingDB Entry DOI: 10.7270/Q2542RNX
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM465380 (US10793567, Compound 16 | US11225479, Compound 16) Show SMILES Nc1ccc(nc1NC(=O)N1Cc2cnc(cc2C1)C(F)F)-c1cccnc1 Show InChI InChI=1S/C19H16F2N6O/c20-17(21)16-6-12-9-27(10-13(12)8-24-16)19(28)26-18-14(22)3-4-15(25-18)11-2-1-5-23-7-11/h1-8,17H,9-10,22H2,(H,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2H998DG
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM465380 (US10793567, Compound 16 | US11225479, Compound 16) Show SMILES Nc1ccc(nc1NC(=O)N1Cc2cnc(cc2C1)C(F)F)-c1cccnc1 Show InChI InChI=1S/C19H16F2N6O/c20-17(21)16-6-12-9-27(10-13(12)8-24-16)19(28)26-18-14(22)3-4-15(25-18)11-2-1-5-23-7-11/h1-8,17H,9-10,22H2,(H,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2H998DG
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM465380 (US10793567, Compound 16 | US11225479, Compound 16) Show SMILES Nc1ccc(nc1NC(=O)N1Cc2cnc(cc2C1)C(F)F)-c1cccnc1 Show InChI InChI=1S/C19H16F2N6O/c20-17(21)16-6-12-9-27(10-13(12)8-24-16)19(28)26-18-14(22)3-4-15(25-18)11-2-1-5-23-7-11/h1-8,17H,9-10,22H2,(H,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rodin Therapeutics, Inc. US Patent					Assay Description The following describes an assay protocol for measuring the deacetylation of a peptide substrate by the enzymes HDAC2 or HDAC1. Enzyme, substrate, an...				US Patent US10793567 (2020) BindingDB Entry DOI: 10.7270/Q2542RNX
					More data for this Ligand-Target Pair