BDBM470562 1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-5-{[3,3-difluorobutan-2-yl]oxy}-2-fluorophenyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylic acid (Racemic)::US10815215, Example 222

SMILES: CCn1c(nn(-c2cc(OC(C)C(C)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O)C(O)=O

InChI Key: InChIKey=JTZZINKWFXPTIR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470562   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM470562 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-5-{[3,3-...) Show SMILES CCn1c(nn(-c2cc(OC(C)C(C)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O)C(O)=O |w:10.10| Show InChI InChI=1S/C22H19ClF4N4O5/c1-4-30-18(20(33)34)29-31(21(30)35)15-9-16(36-10(2)22(3,26)27)11(8-14(15)25)19(32)28-17-12(23)6-5-7-13(17)24/h5-10H,4H2,1-3H3,(H,28,32)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM470562 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-5-{[3,3-...) Show SMILES CCn1c(nn(-c2cc(OC(C)C(C)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O)C(O)=O |w:10.10| Show InChI InChI=1S/C22H19ClF4N4O5/c1-4-30-18(20(33)34)29-31(21(30)35)15-9-16(36-10(2)22(3,26)27)11(8-14(15)25)19(32)28-17-12(23)6-5-7-13(17)24/h5-10H,4H2,1-3H3,(H,28,32)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020)
					More data for this Ligand-Target Pair