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SMILES: Fc1ccc(NC(=O)c2cccc(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key: InChIKey=MWBMHUAZXUNEJB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 473609   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473609
PNG
(US10844062, Example 45)
Show SMILES Fc1ccc(NC(=O)c2cccc(Cl)c2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C23H14ClF2N7O/c24-13-4-1-3-12(9-13)23(34)32-16-7-6-15(25)19(17(16)26)33-21-14(5-2-8-27-21)18-20-22(30-10-28-18)31-11-29-20/h1-11H,(H,27,33)(H,32,34)(H,28,29,30,31)
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US Patent
n/an/a 147n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair