null
SMILES: CNC(=O)[C@@H]1Cc2ncn(c2C(=O)C1)-c1ccc(C#N)c(Cl)c1
InChI Key: InChIKey=DBAWKCBCHMWASW-SNVBAGLBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human)) | BDBM473972 ((R)-1-(3-Chloro-4-cyano- phenyl)-7-oxo-4,5,6,7- te...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p... | US Patent US10858342 (2020) BindingDB Entry DOI: 10.7270/Q2MG7SKT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human)) | BDBM473972 ((R)-1-(3-Chloro-4-cyano- phenyl)-7-oxo-4,5,6,7- te...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio... | US Patent US10858342 (2020) BindingDB Entry DOI: 10.7270/Q2MG7SKT | |||||||||||
More data for this Ligand-Target Pair |